Ontology highlight
ABSTRACT:
SUBMITTER: Wu YM
PROVIDER: S-EPMC3694764 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Wu Yi-Mi YM Su Fengyun F Kalyana-Sundaram Shanker S Khazanov Nickolay N Ateeq Bushra B Cao Xuhong X Lonigro Robert J RJ Vats Pankaj P Wang Rui R Lin Su-Fang SF Cheng Ann-Joy AJ Kunju Lakshmi P LP Siddiqui Javed J Tomlins Scott A SA Wyngaard Peter P Sadis Seth S Roychowdhury Sameek S Hussain Maha H MH Feng Felix Y FY Zalupski Mark M MM Talpaz Moshe M Pienta Kenneth J KJ Rhodes Daniel R DR Robinson Dan R DR Chinnaiyan Arul M AM
Cancer discovery 20130404 6
Through a prospective clinical sequencing program for advanced cancers, four index cases were identified which harbor gene rearrangements of FGFR2, including patients with cholangiocarcinoma, breast cancer, and prostate cancer. After extending our assessment of FGFR rearrangements across multiple tumor cohorts, we identified additional FGFR fusions with intact kinase domains in lung squamous cell cancer, bladder cancer, thyroid cancer, oral cancer, glioblastoma, and head and neck squamous cell c ...[more]