Ontology highlight
ABSTRACT:
SUBMITTER: Ferguson SD
PROVIDER: S-EPMC5961205 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Ferguson Sherise D SD Zhou Shouhao S Huse Jason T JT de Groot John F JF Xiu Joanne J Subramaniam Deepa S DS Mehta Shwetal S Gatalica Zoran Z Swensen Jeffrey J Sanai Nader N Spetzler David D Heimberger Amy B AB
Journal of neuropathology and experimental neurology 20180601 6
Gene fusions involving oncogenes have been reported in gliomas and may serve as novel therapeutic targets. Using RNA-sequencing, we interrogated a large cohort of gliomas to assess for the incidence of targetable genetic fusions. Gliomas (n = 390) were profiled using the ArcherDx FusionPlex Assay. Fifty-two gene targets were analyzed and fusions with preserved kinase domains were investigated. Overall, 36 gliomas (9%) harbored a total of 37 potentially targetable fusions, the majority of which w ...[more]