Ontology highlight
ABSTRACT:
SUBMITTER: Huang N
PROVIDER: S-EPMC3694778 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Huang Nian N Chelliah Yogarany Y Shan Yongli Y Taylor Clinton A CA Yoo Seung-Hee SH Partch Carrie C Green Carla B CB Zhang Hong H Takahashi Joseph S JS
Science (New York, N.Y.) 20120531 6091
The circadian clock in mammals is driven by an autoregulatory transcriptional feedback mechanism that takes approximately 24 hours to complete. A key component of this mechanism is a heterodimeric transcriptional activator consisting of two basic helix-loop-helix PER-ARNT-SIM (bHLH-PAS) domain protein subunits, CLOCK and BMAL1. Here, we report the crystal structure of a complex containing the mouse CLOCK:BMAL1 bHLH-PAS domains at 2.3 Å resolution. The structure reveals an unusual asymmetric hete ...[more]