Ontology highlight
ABSTRACT:
SUBMITTER: Rahrmann EP
PROVIDER: S-EPMC3695033 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Rahrmann Eric P EP Watson Adrienne L AL Keng Vincent W VW Choi Kwangmin K Moriarity Branden S BS Beckmann Dominic A DA Wolf Natalie K NK Sarver Aaron A Collins Margaret H MH Moertel Christopher L CL Wallace Margaret R MR Gel Bernat B Serra Eduard E Ratner Nancy N Largaespada David A DA
Nature genetics 20130519 7
Malignant peripheral nerve sheath tumors (MPNSTs) are sarcomas of Schwann cell lineage origin that occur sporadically or in association with the inherited syndrome neurofibromatosis type 1. To identify genetic drivers of MPNST development, we used the Sleeping Beauty (SB) transposon-based somatic mutagenesis system in mice with somatic loss of transformation-related protein p53 (Trp53) function and/or overexpression of human epidermal growth factor receptor (EGFR). Common insertion site (CIS) an ...[more]