Ontology highlight
ABSTRACT:
SUBMITTER: Wang J
PROVIDER: S-EPMC3695364 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Wang Jinyong J Kong Guangyao G Liu Yangang Y Du Juan J Chang Yuan-I YI Tey Sin Ruow SR Zhang Xinmin X Ranheim Erik A EA Saba-El-Leil Marc K MK Meloche Sylvain S Damnernsawad Alisa A Zhang Jingfang J Zhang Jing J
Blood 20130517 26
Oncogenic NRAS mutations are frequently identified in human myeloid leukemias. In mice, expression of endogenous oncogenic Nras (Nras(G12D/+)) in hematopoietic cells leads to expansion of myeloid progenitors, increased long-term reconstitution of bone marrow cells, and a chronic myeloproliferative neoplasm (MPN). However, acute expression of Nras(G12D/+) in a pure C57BL/6 background does not induce hyperactivated granulocyte macrophage colony-stimulating factor signaling or increased proliferati ...[more]