Ontology highlight
ABSTRACT:
SUBMITTER: Xue YX
PROVIDER: S-EPMC3695463 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20120401 6078
Drug use and relapse involve learned associations between drug-associated environmental cues and drug effects. Extinction procedures in the clinic can suppress conditioned responses to drug cues, but the extinguished responses typically reemerge after exposure to the drug itself (reinstatement), the drug-associated environment (renewal), or the passage of time (spontaneous recovery). We describe a memory retrieval-extinction procedure that decreases conditioned drug effects and drug seeking in r ...[more]