Ontology highlight
ABSTRACT:
SUBMITTER: Gong Z
PROVIDER: S-EPMC3695484 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Gong Zihua Z Kim Ja-Eun JE Leung Charles Chung Yun CC Glover J N Mark JN Chen Junjie J
Molecular cell 20100201 3
Human TopBP1 plays a critical role in the control of DNA replication checkpoint. In this study, we report a specific interaction between TopBP1 and BACH1/FANCJ, a DNA helicase involved in the repair of DNA crosslinks. The TopBP1/BACH1 interaction is mediated by the very C-terminal tandem BRCT domains of TopBP1 and S phase-specific phosphorylation of BACH1 at Thr 1133 site. Interestingly, we demonstrate that depletion of TopBP1 or BACH1 attenuates the loading of RPA on chromatin. Moreover, both T ...[more]