Ontology highlight
ABSTRACT:
SUBMITTER: Bertucci PY
PROVIDER: S-EPMC3695497 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Bertucci Paola Y PY Nacht A Silvina AS Alló Mariano M Rocha-Viegas Luciana L Ballaré Cecilia C Soronellas Daniel D Castellano Giancarlo G Zaurin Roser R Kornblihtt Alberto R AR Beato Miguel M Vicent Guillermo P GP Pecci Adali A
Nucleic acids research 20130502 12
Steroid receptors were classically described for regulating transcription by binding to target gene promoters. However, genome-wide studies reveal that steroid receptors-binding sites are mainly located at intragenic regions. To determine the role of these sites, we examined the effect of progestins on the transcription of the bcl-x gene, where only intragenic progesterone receptor-binding sites (PRbs) were identified. We found that in response to hormone treatment, the PR is recruited to these ...[more]