Ontology highlight
ABSTRACT:
SUBMITTER: Owens P
PROVIDER: S-EPMC3695869 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Owens Philip P Polikowsky Hannah H Pickup Michael W MW Gorska Agnieszka E AE Jovanovic Bojana B Shaw Aubie K AK Novitskiy Sergey V SV Hong Charles C CC Moses Harold L HL
PloS one 20130628 6
Bone Morphogenetic Proteins (BMPs) are secreted cytokines that are part of the Transforming Growth Factor β (TGFβ) superfamily. BMPs have been shown to be highly expressed in human breast cancers, and loss of BMP signaling in mammary carcinomas has been shown to accelerate metastases. Interestingly, other work has indicated that stimulation of dermal fibroblasts with BMP can enhance secretion of pro-tumorigenic factors. Furthermore, treatment of carcinoma-associated fibroblasts (CAFs) derived fr ...[more]