Ontology highlight
ABSTRACT:
SUBMITTER: Huang B
PROVIDER: S-EPMC3697905 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Huang B B Qu Z Z Ong C W CW Tsang Y-H N YH Xiao G G Shapiro D D Salto-Tellez M M Ito K K Ito Y Y Chen L-F LF
Oncogene 20110627 4
Transcription factor RUNX3 is inactivated in a number of malignancies, including breast cancer, and is suggested to function as a tumor suppressor. How RUNX3 functions as a tumor suppressor in breast cancer remains undefined. Here, we show that about 20% of female Runx3(+/-) mice spontaneously developed ductal carcinoma at an average age of 14.5 months. Additionally, RUNX3 inhibits the estrogen-dependent proliferation and transformation potential of ERα-positive MCF-7 breast cancer cells in liqu ...[more]