Ontology highlight
ABSTRACT:
SUBMITTER: Braeunig JH
PROVIDER: S-EPMC3698094 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
PloS one 20130701 7
Adenylyl cyclase type 5 (AC5) was described as major cardiac AC isoform. The knockout of AC5 (AC5KO) exerted cardioprotective effects in heart failure. Our study explored the impact of AC5KO on mouse heart AC activities and evaluated putative AC5-selective inhibitors. In cardiac membranes from AC5KO mice, basal AC activity was decreased, while AC stimulation was intact. The putative AC5-selective P-site inhibitors SQ22,536 [9-(tetra-hydro-2-furanyl)-9H-purin-6-amine], vidarabine (9-β-D-arabinosy ...[more]