Ontology highlight
ABSTRACT:
SUBMITTER: Schlicker C
PROVIDER: S-EPMC3082441 | biostudies-literature | 2008 Aug
REPOSITORIES: biostudies-literature
Journal of medicinal chemistry 20080717 15
In mammals, the second messenger cAMP is synthesized by a family of transmembrane isoforms (tmACs) and one known cytoplasmic enzyme, "soluble" adenylyl cyclase (sAC). Understanding the individual contributions of these families to cAMP signaling requires tools which can distinguish them. Here, we describe the structure-based development of isoform discriminating AC inhibitors. Docking calculations using a library of small molecules with the crystal structure of a sAC homologue complexed with the ...[more]