Ontology highlight
ABSTRACT:
SUBMITTER: Winter DR
PROVIDER: S-EPMC3698505 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Winter Deborah R DR Song Lingyun L Mukherjee Sayan S Furey Terrence S TS Crawford Gregory E GE
Genome research 20130508 7
DNase-seq is primarily used to identify nucleosome-depleted DNase I hypersensitive (DHS) sites genome-wide that correspond to active regulatory elements. However, ≈ 40 yr ago it was demonstrated that DNase I also digests with a ≈ 10-bp periodicity around nucleosomes matching the exposure of the DNA minor groove as it wraps around histones. Here, we use DNase-seq data from 49 samples representing diverse cell types to reveal this digestion pattern at individual loci and predict genomic locations ...[more]