Heteroadamantyl cannabinoids.
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ABSTRACT:
SUBMITTER: Dixon DD
PROVIDER: S-EPMC3699191 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Publications
Heteroadamantyl cannabinoids.
Dixon Darryl D DD Sethumadhavan Divakaramenon D Benneche Tore T Banaag April R AR Tius Marcus A MA Thakur Ganesh A GA Bowman Anna A Wood Jodianne T JT Makriyannis Alexandros A
Journal of medicinal chemistry 20100801 15
The aliphatic side chain plays a pivotal role in determining the cannabinergic potency of tricyclic classical cannabinoids. We have synthesized a series of analogues in which the C3 position is substituted either directly or through a one-carbon atom linker with an adamantylamine or with an oxa- or an oxazaadamantane. The oxaadamantane pharmacophore in analogue 16 showed the best binding profile for both receptors. ...[more]
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