Ontology highlight
ABSTRACT:
SUBMITTER: Zhang MM
PROVIDER: S-EPMC3699447 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Zhang Mingzi M MM Zhang Mingzi M MM Wu Pei-Yun Jenny PY Kelly Felice D FD Nurse Paul P Hang Howard C HC
PLoS biology 20130702 7
Protein S-palmitoylation, a lipid modification mediated by members of the palmitoyltransferase family, serves as an important membrane-targeting mechanism in eukaryotes. Although changes in palmitoyltransferase expression are associated with various physiological and disease states, how these changes affect global protein palmitoylation and cellular function remains unknown. Using a bioorthogonal chemical reporter and labeling strategy to identify and analyze multiple cognate substrates of a sin ...[more]