Ontology highlight
ABSTRACT:
SUBMITTER: Wallace BD
PROVIDER: S-EPMC3699901 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Wallace Bret D BD Betts Laurie L Talmage Garrick G Pollet Rebecca M RM Holman Natalie S NS Redinbo Matthew R MR
Journal of molecular biology 20130416 14
The human nuclear xenobiotic receptor PXR recognizes a range of potentially harmful drugs and endobiotic chemicals but must complex with the nuclear receptor RXRα to control the expression of numerous drug metabolism genes. To date, the structural basis and functional consequences of this interaction have remained unclear. Here we present 2.8-Å-resolution crystal structures of the heterodimeric complex formed between the ligand-binding domains of human PXR and RXRα. These structures establish th ...[more]