Ontology highlight
ABSTRACT:
SUBMITTER: Banerjee M
PROVIDER: S-EPMC4433851 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Banerjee Monimoy M Robbins Delira D Chen Taosheng T
Drug discovery today 20141120 5
Nuclear receptors such as the pregnane X receptor (PXR) and constitutive androstane receptor (CAR) are xenobiotic receptors regulating not only drug metabolism and disposition but also various human diseases such as cancer, diabetes, inflammatory disease, metabolic disease and liver diseases, suggesting that PXR and CAR are promising targets for drug discovery. Consequently, there is an urgent need to discover and develop small molecules that target these PXR- and/or CAR-mediated human-disease-r ...[more]