Ontology highlight
ABSTRACT:
SUBMITTER: Muller S
PROVIDER: S-EPMC3700226 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Müller Sebastian S Sanders Deborah A DA Di Antonio Marco M Matsis Stephanos S Riou Jean-François JF Rodriguez Raphaël R Balasubramanian Shankar S
Organic & biomolecular chemistry 20120713 32
The synthesis, biophysical and biological evaluation of a series of G-quadruplex interacting small molecules based on a N,N'-bis(quinolinyl)pyridine-2,6-dicarboxamide scaffold is described. The synthetic analogues were evaluated for their ability to stabilize telomeric G-quadruplex DNA, some of which showed very high stabilization potential associated with high selectivity over double-stranded DNA. The compounds exhibited growth arrest of cancer cells with detectable selectivity over normal cell ...[more]