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Acute Kidney Injury Results in Long-Term Diastolic Dysfunction That Is Prevented by Histone Deacetylase Inhibition.

ABSTRACT: Growing epidemiological data demonstrate that acute kidney injury (AKI) is associated with long-term cardiovascular morbidity and mortality. Here, the authors present a 1-year study of cardiorenal outcomes following bilateral ischemia-reperfusion injury in male mice. These data suggest that AKI causes long-term dysfunction in the cardiac metabolome, which is associated with diastolic dysfunction and hypertension. Mice treated with the histone deacetylase inhibitor, ITF2357, had preservation of cardiac function and remained normotensive throughout the study. ITF2357 did not protect against the development of kidney fibrosis after AKI.

SUBMITTER: Soranno DE

PROVIDER: S-EPMC7907538 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature

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Acute Kidney Injury Results in Long-Term Diastolic Dysfunction That Is Prevented by Histone Deacetylase Inhibition.

Soranno Danielle E DE Kirkbride-Romeo Lara L Wennersten Sara A SA Ding Kathy K Cavasin Maria A MA Baker Peter P Altmann Christopher C Bagchi Rushita A RA Haefner Korey R KR Steinkühler Christian C Montford John R JR Keith Brysen B Gist Katja M KM McKinsey Timothy A TA Faubel Sarah S

JACC. Basic to translational science 20210222 2

Growing epidemiological data demonstrate that acute kidney injury (AKI) is associated with long-term cardiovascular morbidity and mortality. Here, the authors present a 1-year study of cardiorenal outcomes following bilateral ischemia-reperfusion injury in male mice. These data suggest that AKI causes long-term dysfunction in the cardiac metabolome, which is associated with diastolic dysfunction and hypertension. Mice treated with the histone deacetylase inhibitor, ITF2357, had preservation of c ...[more]

PMID: 33665513

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