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MicroRNA-mediated control of macrophages and its implications for cancer.

ABSTRACT: Deregulation of microRNAs (miRNAs) can drive oncogenesis, tumor progression, and metastasis by acting cell-autonomously in cancer cells. However, solid tumors are also infiltrated by large amounts of non-neoplastic stromal cells, including macrophages, which express several active miRNAs. Tumor-associated macrophages (TAMs) enhance angiogenic, immunosuppressive, invasive, and metastatic programming of neoplastic tissue and reduce host survival. Here, we review the role of miRNAs (including miR-155, miR-146, and miR-511) in the control of macrophage production and activation, and examine whether reprogramming miRNA activity in TAMs and/or their precursors might be effective for controlling tumor progression.

SUBMITTER: Squadrito ML

PROVIDER: S-EPMC3700601 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature

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MicroRNA-mediated control of macrophages and its implications for cancer.

Squadrito Mario Leonardo ML Etzrodt Martin M De Palma Michele M Pittet Mikael J MJ

Trends in immunology 20130313 7

Deregulation of microRNAs (miRNAs) can drive oncogenesis, tumor progression, and metastasis by acting cell-autonomously in cancer cells. However, solid tumors are also infiltrated by large amounts of non-neoplastic stromal cells, including macrophages, which express several active miRNAs. Tumor-associated macrophages (TAMs) enhance angiogenic, immunosuppressive, invasive, and metastatic programming of neoplastic tissue and reduce host survival. Here, we review the role of miRNAs (including miR-1 ...[more]

PMID: 23498847

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