Ontology highlight
ABSTRACT:
SUBMITTER: Lutter EI
PROVIDER: S-EPMC3700685 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Lutter Erika I EI Barger Alexandra C AC Nair Vinod V Hackstadt Ted T
Cell reports 20130530 6
Chlamydia trachomatis replicates within a membrane-bound compartment termed an inclusion. The inclusion membrane is modified by the insertion of multiple proteins known as Incs. In a yeast two-hybrid screen, an interaction was found between the inclusion membrane protein CT228 and MYPT1, a subunit of myosin phosphatase. MYPT1 was recruited peripherally around the inclusion, whereas the phosphorylated, inactive form was localized to active Src-family kinase-rich microdomains. Phosphorylated myosi ...[more]