Ontology highlight
ABSTRACT:
SUBMITTER: Elvers M
PROVIDER: S-EPMC3701458 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Elvers Margitta M Stegner David D Hagedorn Ina I Kleinschnitz Christoph C Braun Attila A Kuijpers Marijke E J ME Boesl Michael M Chen Qin Q Heemskerk Johan W M JW Stoll Guido G Frohman Michael A MA Nieswandt Bernhard B
Science signaling 20100105 103
Platelet aggregation is essential for hemostasis but can also cause myocardial infarction and stroke. A key but poorly understood step in platelet activation is the shift of the principal adhesive receptor, alpha(IIb)beta(3) integrin, from a low- to high-affinity state for its ligands, a process that enables adhesion and aggregation. In response to stimulation of heterotrimeric guanosine triphosphate-binding protein or immunoreceptor tyrosine-based activation motif-coupled receptors, phospholipa ...[more]