Ontology highlight
ABSTRACT:
SUBMITTER: Leung LC
PROVIDER: S-EPMC3701881 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Leung Louis C LC Urbančič Vasja V Baudet Marie-Laure ML Dwivedy Asha A Bayley Timothy G TG Lee Aih Cheun AC Harris William A WA Holt Christine E CE
Nature neuroscience 20130106 2
Cell adhesion molecules and diffusible cues both regulate axon pathfinding, yet how these two modes of signaling interact is poorly understood. The homophilic cell adhesion molecule NF-protocadherin (NFPC) is expressed in the mid-dorsal optic tract neuroepithelium and in the axons of developing retinal ganglion cells (RGC) in Xenopus laevis. Here we report that targeted disruption of NFPC function in RGC axons or the optic tract neuroepithelium results in unexpectedly localized pathfinding defec ...[more]