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Prognostic relevance of integrated genetic profiling in adult T-cell acute lymphoblastic leukemia.

ABSTRACT: Adult T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic tumor associated with poor outcome. In this study, we analyzed the prognostic relevance of genetic alterations, immunophenotypic markers, and microarray gene expression signatures in a panel of 53 adult T-ALL patients treated in the Eastern Cooperative Oncology Group E2993 clinical trial. An early immature gene expression signature, the absence of bi-allelic TCRG deletion, CD13 surface expression, heterozygous deletions of the short arm of chromosome 17, and mutations in IDH1/IDH2 and DNMT3A genes are associated with poor prognosis in this series. In contrast, expression of CD8 or CD62L, homozygous deletion of CDKN2A/CDKN2B, NOTCH1 and/or FBXW7 mutations, and mutations or deletions in the BCL11B tumor suppressor gene were associated with improved overall survival. Importantly, the prognostic relevance of CD13 expression and homozygous CDKN2A/CDKN2B deletions was restricted to cortical and mature T-ALLs. Conversely, mutations in IDH1/IDH2 and DNMT3A were specifically associated with poor outcome in early immature adult T-ALLs. This trial was registered at www.clinicaltrials.gov as #NCT00002514.

SUBMITTER: Van Vlierberghe P

PROVIDER: S-EPMC3701905 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature

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Prognostic relevance of integrated genetic profiling in adult T-cell acute lymphoblastic leukemia.

Van Vlierberghe Pieter P Ambesi-Impiombato Alberto A De Keersmaecker Kim K Hadler Michael M Paietta Elisabeth E Tallman Martin S MS Rowe Jacob M JM Forne Carles C Rue Montserrat M Ferrando Adolfo A AA

Blood 20130517 1

Adult T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic tumor associated with poor outcome. In this study, we analyzed the prognostic relevance of genetic alterations, immunophenotypic markers, and microarray gene expression signatures in a panel of 53 adult T-ALL patients treated in the Eastern Cooperative Oncology Group E2993 clinical trial. An early immature gene expression signature, the absence of bi-allelic TCRG deletion, CD13 surface expression, heterozygous deletio ...[more]

PMID: 23687089

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Prognostic relevance of integrated genetic profiling in adult T-cell acute lymphoblastic leukemia.

Publications

Prognostic relevance of integrated genetic profiling in adult T-cell acute lymphoblastic leukemia.

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