Ontology highlight
ABSTRACT:
SUBMITTER: Patel JP
PROVIDER: S-EPMC3545649 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Patel Jay P JP Gönen Mithat M Figueroa Maria E ME Fernandez Hugo H Sun Zhuoxin Z Racevskis Janis J Van Vlierberghe Pieter P Dolgalev Igor I Thomas Sabrena S Aminova Olga O Huberman Kety K Cheng Janice J Viale Agnes A Socci Nicholas D ND Heguy Adriana A Cherry Athena A Vance Gail G Higgins Rodney R RR Ketterling Rhett P RP Gallagher Robert E RE Litzow Mark M van den Brink Marcel R M MR Lazarus Hillard M HM Rowe Jacob M JM Luger Selina S Ferrando Adolfo A Paietta Elisabeth E Tallman Martin S MS Melnick Ari A Abdel-Wahab Omar O Levine Ross L RL
The New England journal of medicine 20120314 12
<h4>Background</h4>Acute myeloid leukemia (AML) is a heterogeneous disease with respect to presentation and clinical outcome. The prognostic value of recently identified somatic mutations has not been systematically evaluated in a phase 3 trial of treatment for AML.<h4>Methods</h4>We performed a mutational analysis of 18 genes in 398 patients younger than 60 years of age who had AML and who were randomly assigned to receive induction therapy with high-dose or standard-dose daunorubicin. We valid ...[more]