Ontology highlight
ABSTRACT:
SUBMITTER: Yang C
PROVIDER: S-EPMC3703473 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Yang Chao C Mi Jiaqi J Feng You Y Ngo Liza L Gao Tielong T Yan Leilei L Zheng Yujun George YG
Journal of the American Chemical Society 20130516 21
Elucidating biological and pathological functions of protein lysine acetyltransferases (KATs) greatly depends on the knowledge of the dynamic and spatial localization of their enzymatic targets in the cellular proteome. We report the design and application of chemical probes for facile labeling and detection of substrates of the three major human KAT enzymes. In this approach, we create engineered KATs in junction with synthetic Ac-CoA surrogates to effectively label KAT substrates even in the p ...[more]