Unknown

Dataset Information

0

Multicenter standardized 18F-FDG PET diagnosis of mild cognitive impairment, Alzheimer's disease, and other dementias.


ABSTRACT: This multicenter study examined (18)F-FDG PET measures in the differential diagnosis of Alzheimer's disease (AD), frontotemporal dementia (FTD), and dementia with Lewy bodies (DLB) from normal aging and from each other and the relation of disease-specific patterns to mild cognitive impairment (MCI).We examined the (18)F-FDG PET scans of 548 subjects, including 110 healthy elderly individuals ("normals" or NLs), 114 MCI, 199 AD, 98 FTD, and 27 DLB patients, collected at 7 participating centers. Individual PET scans were Z scored using automated voxel-based comparison with generation of disease-specific patterns of cortical and hippocampal (18)F-FDG uptake that were then applied to characterize MCI.Standardized disease-specific PET patterns were developed that correctly classified 95% AD, 92% DLB, 94% FTD, and 94% NL. MCI patients showed primarily posterior cingulate cortex and hippocampal hypometabolism (81%), whereas neocortical abnormalities varied according to neuropsychological profiles. An AD PET pattern was observed in 79% MCI with deficits in multiple cognitive domains and 31% amnesic MCI. (18)F-FDG PET heterogeneity in MCI with nonmemory deficits ranged from absent hypometabolism to FTD and DLB PET patterns.Standardized automated analysis of (18)F-FDG PET scans may provide an objective and sensitive support to the clinical diagnosis in early dementia.

SUBMITTER: Mosconi L 

PROVIDER: S-EPMC3703818 | biostudies-literature | 2008 Mar

REPOSITORIES: biostudies-literature

altmetric image

Publications

Multicenter standardized 18F-FDG PET diagnosis of mild cognitive impairment, Alzheimer's disease, and other dementias.

Mosconi Lisa L   Tsui Wai H WH   Herholz Karl K   Pupi Alberto A   Drzezga Alexander A   Lucignani Giovanni G   Reiman Eric M EM   Holthoff Vjera V   Kalbe Elke E   Sorbi Sandro S   Diehl-Schmid Janine J   Perneczky Robert R   Clerici Francesca F   Caselli Richard R   Beuthien-Baumann Bettina B   Kurz Alexander A   Minoshima Satoshi S   de Leon Mony J MJ  

Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20080220 3


<h4>Unlabelled</h4>This multicenter study examined (18)F-FDG PET measures in the differential diagnosis of Alzheimer's disease (AD), frontotemporal dementia (FTD), and dementia with Lewy bodies (DLB) from normal aging and from each other and the relation of disease-specific patterns to mild cognitive impairment (MCI).<h4>Methods</h4>We examined the (18)F-FDG PET scans of 548 subjects, including 110 healthy elderly individuals ("normals" or NLs), 114 MCI, 199 AD, 98 FTD, and 27 DLB patients, coll  ...[more]

Similar Datasets

| S-EPMC9984631 | biostudies-literature
| S-EPMC6218118 | biostudies-other
| S-EPMC9969139 | biostudies-literature
| S-EPMC2693402 | biostudies-other
| S-EPMC7512221 | biostudies-literature
| S-EPMC7574434 | biostudies-literature
| S-EPMC5553544 | biostudies-other
| S-EPMC8625716 | biostudies-literature
| S-EPMC7902948 | biostudies-literature