Ontology highlight
ABSTRACT:
SUBMITTER: Rubinski A
PROVIDER: S-EPMC7574434 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Alzheimer's research & therapy 20201019 1
<h4>Background</h4>FDG-PET hypermetabolism can be observed in mild cognitive impairment (MCI), but the link to primary pathologies of Alzheimer's diseases (AD) including amyloid and tau is unclear.<h4>Methods</h4>Using voxel-based regression, we assessed local interactions between amyloid- and tau-PET on spatially matched FDG-PET in 72 MCI patients. Control groups included cerebrospinal fluid biomarker characterized cognitively normal (CN, n = 70) and AD dementia subjects (n = 95).<h4>Results</h ...[more]