Ontology highlight
ABSTRACT:
SUBMITTER: Zhao X
PROVIDER: S-EPMC3703971 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Zhao Xuannv X Wang Dongmei D Liu Xing X Liu Lifang L Song Zhenwei Z Zhu Tongge T Adams Gregory G Gao Xinjiao X Tian Ruijun R Huang Yuejia Y Chen Runhua R Wang Fengsong F Liu Dong D Yu Xue X Chen Yong Y Chen Zhengjun Z Teng Maikun M Ding Xia X Yao Xuebiao X
Proceedings of the National Academy of Sciences of the United States of America 20130617 27
ArfGAP With Coiled-Coil, Ankyrin Repeat And PH Domains 4 (ACAP4) is an ADP-ribosylation factor 6 (ARF6) GTPase-activating protein essential for EGF-elicited cell migration. However, how ACAP4 regulates membrane dynamics and curvature in response to EGF stimulation is unknown. Here, we show that phosphorylation of the N-terminal region of ACAP4, named the Bin, Amphiphysin, and RSV161/167 (BAR) domain, at Tyr34 is necessary for EGF-elicited membrane remodeling. Domain structure analysis demonstrat ...[more]