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Bin/Amphiphysin/Rvs (BAR) family members bend membranes in cells.

ABSTRACT: We provide direct evidence that Bin/Amphiphysin/Rvs (BAR) family members bend the steady state membrane architecture of organelles in intact cells. In response to inducible BAR molecular actuators, organelles exhibit distinct changes to the orientation and degree of their membrane curvature. This rapidly inducible system may offer a mechanism by which to better understand the structure-function relationship of intracellular organelles.

SUBMITTER: Suarez A 

PROVIDER: S-EPMC4894391 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature

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Bin/Amphiphysin/Rvs (BAR) family members bend membranes in cells.

Suarez Allison A   Ueno Tasuku T   Huebner Robert R   McCaffery J Michael JM   Inoue Takanari T  

Scientific reports 20140506

We provide direct evidence that Bin/Amphiphysin/Rvs (BAR) family members bend the steady state membrane architecture of organelles in intact cells. In response to inducible BAR molecular actuators, organelles exhibit distinct changes to the orientation and degree of their membrane curvature. This rapidly inducible system may offer a mechanism by which to better understand the structure-function relationship of intracellular organelles. ...[more]

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