Ontology highlight
ABSTRACT:
SUBMITTER: Zhang DD
PROVIDER: S-EPMC3704121 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Antioxidants & redox signaling 20130111 5
The targeted activation of nuclear factor erythroid-derived-2-like 2 (Nrf2) to alleviate symptoms of chronic kidney disease has recently garnered much attention. Unfortunately, the greatest clinical success to date, bardoxolone, failed in phase III clinical trial for unspecified safety reasons. The present letter to the editor discusses the clinical development of bardoxolone and explores potential reasons for the ultimate withdrawal from clinical trials. In particular, was the correct clinical ...[more]