Ontology highlight
ABSTRACT:
SUBMITTER: Kohler C
PROVIDER: S-EPMC5841080 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Köhler Christian C Lighthouse Janet K JK Werther Tobias T Andersen Olav M OM Diehl Annette A Schmieder Peter P Du Jianguang J Holdener Bernadette C BC Oschkinat Hartmut H
Structure (London, England : 1993) 20110301 3
Mesoderm development (MESD) is a 224 amino acid mouse protein that acts as a molecular chaperone for the low-density lipoprotein receptor (LDLR) family. Here, we provide evidence that the region 45-184 of MESD is essential and sufficient for this function and suggest a model for its mode of action. NMR studies reveal a β-α-β-β-α-β core domain with an α-helical N-terminal extension that interacts with the β sheet in a dynamic manner. As a result, the structural ensemble contains open (active) and ...[more]