Ontology highlight
ABSTRACT:
SUBMITTER: Park YH
PROVIDER: S-EPMC3704122 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Park Young-Ho YH Kim Sun-Uk SU Lee Bo-Kyoung BK Kim Hyun-Sun HS Song In-Sung IS Shin Hye-Jun HJ Han Ying-Hao YH Chang Kyu-Tae KT Kim Jin-Man JM Lee Dong-Seok DS Kim Yeul-Hong YH Choi Chang-Min CM Kim Bo-Yeon BY Yu Dae-Yeul DY
Antioxidants & redox signaling 20130613 5
<h4>Aims</h4>Coupled responses of mutated K-ras and oxidative stress are often an important etiological factor in non-small-cell lung cancer (NSCLC). However, relatively few studies have examined the control mechanism of oxidative stress in oncogenic K-ras-driven NSCLC progression. Here, we studied whether the redox signaling pathway governed by peroxiredoxin I (Prx I) is involved in K-ras(G12D)-mediated lung adenocarcinogenesis.<h4>Results</h4>Using human-lung adenocarcinoma tissues and lung-sp ...[more]