Ontology highlight
ABSTRACT:
SUBMITTER: Tschandl P
PROVIDER: S-EPMC3704624 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Tschandl Philipp P Berghoff Anna Sophie AS Preusser Matthias M Burgstaller-Muehlbacher Sebastian S Pehamberger Hubert H Okamoto Ichiro I Kittler Harald H
PloS one 20130708 7
According to the prevailing multistep model of melanoma development, oncogenic BRAF or NRAS mutations are crucial initial events in melanoma development. It is not known whether melanocytic nevi that are found in association with a melanoma are more likely to carry BRAF or NRAS mutations than uninvolved nevi. By laser microdissection we were able to selectively dissect and genotype cells either from the nevus or from the melanoma part of 46 melanomas that developed in association with a nevus. I ...[more]