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Angiotensin II AT(2) receptor decreases AT(1) receptor expression and function via nitric oxide/cGMP/Sp1 in renal proximal tubule cells from Wistar-Kyoto rats.


ABSTRACT: The renin-angiotensin (Ang) system controls blood pressure, in part, by regulating renal tubular sodium transport. In the kidney, activation of the angiotensin II type 1 (AT(1)) receptor increases renal sodium reabsorption, whereas the angiotensin II type 2 (AT(2)) receptor produces the opposite effect. We hypothesized that the AT(2) receptor regulates AT(1) receptor expression and function in the kidney.In immortalized renal proximal tubule (RPT) cells from Wistar-Kyoto rats, CGP42112, an AT(2) receptor agonist, decreased AT(1) receptor mRNA and protein expression (P?

SUBMITTER: Yang J 

PROVIDER: S-EPMC3705562 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature

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Angiotensin II AT(2) receptor decreases AT(1) receptor expression and function via nitric oxide/cGMP/Sp1 in renal proximal tubule cells from Wistar-Kyoto rats.

Yang Jian J   Chen Caiyu C   Ren Hongmei H   Han Yu Y   He Duofen D   Zhou Lin L   Hopfer Ulrich U   Jose Pedro A PA   Zeng Chunyu C  

Journal of hypertension 20120601 6


<h4>Background</h4>The renin-angiotensin (Ang) system controls blood pressure, in part, by regulating renal tubular sodium transport. In the kidney, activation of the angiotensin II type 1 (AT(1)) receptor increases renal sodium reabsorption, whereas the angiotensin II type 2 (AT(2)) receptor produces the opposite effect. We hypothesized that the AT(2) receptor regulates AT(1) receptor expression and function in the kidney.<h4>Methods and results</h4>In immortalized renal proximal tubule (RPT) c  ...[more]

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