Angiotensin II AT(2) receptor decreases AT(1) receptor expression and function via nitric oxide/cGMP/Sp1 in renal proximal tubule cells from Wistar-Kyoto rats.
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SUBMITTER: Yang J
PROVIDER: S-EPMC3705562 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
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Angiotensin II AT(2) receptor decreases AT(1) receptor expression and function via nitric oxide/cGMP/Sp1 in renal proximal tubule cells from Wistar-Kyoto rats.
Yang Jian J Chen Caiyu C Ren Hongmei H Han Yu Y He Duofen D Zhou Lin L Hopfer Ulrich U Jose Pedro A PA Zeng Chunyu C
Journal of hypertension 20120601 6
<h4>Background</h4>The renin-angiotensin (Ang) system controls blood pressure, in part, by regulating renal tubular sodium transport. In the kidney, activation of the angiotensin II type 1 (AT(1)) receptor increases renal sodium reabsorption, whereas the angiotensin II type 2 (AT(2)) receptor produces the opposite effect. We hypothesized that the AT(2) receptor regulates AT(1) receptor expression and function in the kidney.<h4>Methods and results</h4>In immortalized renal proximal tubule (RPT) c ...[more]
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