Ontology highlight
ABSTRACT:
SUBMITTER: Diner EJ
PROVIDER: S-EPMC3706192 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Diner Elie J EJ Burdette Dara L DL Wilson Stephen C SC Monroe Kathryn M KM Kellenberger Colleen A CA Hyodo Mamoru M Hayakawa Yoshihiro Y Hammond Ming C MC Vance Russell E RE
Cell reports 20130523 5
The presence of foreign DNA in the cytosol of mammalian cells elicits a potent antiviral interferon response. Recently, cytosolic DNA was proposed to induce the synthesis of cyclic GMP-AMP (cGAMP) upon binding to an enzyme called cGAMP synthase (cGAS). cGAMP activates an interferon response by binding to a downstream receptor called STING. Here, we identify natural variants of human STING (hSTING) that are poorly responsive to cGAMP yet, unexpectedly, are normally responsive to DNA and cGAS sign ...[more]