Ontology highlight
ABSTRACT:
SUBMITTER: Liu D
PROVIDER: S-EPMC6748081 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Liu Dong D Wu Hao H Wang Chenguang C Li Yanjun Y Tian Huabin H Siraj Sami S Sehgal Sheikh Arslan SA Wang Xiaohui X Wang Jun J Shang Yingli Y Jiang Zhengfan Z Liu Lei L Chen Quan Q
Cell death and differentiation 20181219 9
STING (stimulator of interferon genes) is a central molecule that binds to cyclic dinucleotides produced by the cyclic GMP-AMP synthase (cGAS) to activate innate immunity against microbial infection. Here we report that STING harbors classic LC-3 interacting regions (LIRs) and mediates autophagy through its direct interaction with LC3. We observed that poly(dA:dT), cGAMP, and HSV-1 induced STING-dependent autophagy and degradation of STING immediately after TBK1 activation. STING induces non-can ...[more]