Role of complement in host-microbe homeostasis of the periodontium.
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ABSTRACT:
SUBMITTER: Hajishengallis G
PROVIDER: S-EPMC3706506 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Publications
Role of complement in host-microbe homeostasis of the periodontium.
Hajishengallis George G Abe Toshiharu T Maekawa Tomoki T Hajishengallis Evlambia E Lambris John D JD
Seminars in immunology 20130201 1
Complement plays a key role in immunity and inflammation through direct effects on immune cells or via crosstalk and regulation of other host signaling pathways. Deregulation of these finely balanced complement activities can link infection to inflammatory tissue damage. Periodontitis is a polymicrobial community-induced chronic inflammatory disease that can destroy the tooth-supporting tissues. In this review, we summarize and discuss evidence that complement is involved in the dysbiotic transf ...[more]
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