Ontology highlight
ABSTRACT:
SUBMITTER: Miyoshi H
PROVIDER: S-EPMC3706630 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
Miyoshi Hiroyuki H Ajima Rieko R Luo Christine T CT Yamaguchi Terry P TP Stappenbeck Thaddeus S TS
Science (New York, N.Y.) 20120906 6103
Reestablishing homeostasis after tissue damage depends on the proper organization of stem cells and their progeny, though the repair mechanisms are unclear. The mammalian intestinal epithelium is well suited to approach this problem, as it is composed of well-delineated units called crypts of Lieberkühn. We found that Wnt5a, a noncanonical Wnt ligand, was required for crypt regeneration after injury in mice. Unlike controls, Wnt5a-deficient mice maintained an expanded population of proliferative ...[more]