Ontology highlight
ABSTRACT:
SUBMITTER: Jain U
PROVIDER: S-EPMC6555552 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Jain Umang U Lai Chin-Wen CW Xiong Shanshan S Goodwin Victoria M VM Lu Qiuhe Q Muegge Brian D BD Christophi George P GP VanDussen Kelli L KL Cummings Bethany P BP Young Erick E Hambor John J Stappenbeck Thaddeus S TS
Cell host & microbe 20180816 3
Colonic wound repair is an orchestrated process, beginning with barrier re-establishment and followed by wound channel formation and crypt regeneration. Elevated levels of prostaglandin E2 (PGE2) promote barrier re-establishment; however, we found that persistently elevated PGE2 hinders subsequent repair phases. The bacterial metabolite deoxycholate (DCA) promotes transition through repair phases via PGE2 regulation. During barrier re-establishment, DCA levels are locally diminished in the wound ...[more]