A multistage genetic association study identifies breast cancer risk loci at 10q25 and 16q24.

ABSTRACT:

Background

Heritable risk for breast cancer includes an increasing number of common, low effect risk variants. We conducted a multistage genetic association study in a series of independent epidemiologic breast cancer study populations to identify novel breast cancer risk variants.

Methods

We tested 1,162 SNPs of greatest nominal significance from stage I of the Cancer Genetic Markers of Susceptibility breast cancer study (CGEMS; 1,145 cases, 1,142 controls) for evidence of replicated association with breast cancer in the Nashville Breast Cohort (NBC; 599 cases, 1,161 controls), the Collaborative Breast Cancer Study (CBCS; 1,552 cases, 1,185 controls), and BioVU Breast Cancer Study (BioVU; 1,172 cases, 1,172 controls).

Results

Among these SNPs, a series of validated b

SUBMITTER: Higginbotham KS 

PROVIDER: S-EPMC3707501 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature