Association analysis identifies 65 new breast cancer risk loci.
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ABSTRACT:
SUBMITTER: Michailidou K
PROVIDER: S-EPMC5798588 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
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Association analysis identifies 65 new breast cancer risk loci.
Michailidou Kyriaki K Lindström Sara S Dennis Joe J Beesley Jonathan J Hui Shirley S Kar Siddhartha S Lemaçon Audrey A Soucy Penny P Glubb Dylan D Rostamianfar Asha A Bolla Manjeet K MK Wang Qin Q Tyrer Jonathan J Dicks Ed E Lee Andrew A Wang Zhaoming Z Allen Jamie J Keeman Renske R Eilber Ursula U French Juliet D JD Qing Chen Xiao X Fachal Laura L McCue Karen K McCart Reed Amy E AE Ghoussaini Maya M Carroll Jason S JS Jiang Xia X Finucane Hilary H Adams Marcia M Adank Muriel A MA Ahsan Habibul H Aittomäki Kristiina K Anton-Culver Hoda H Antonenkova Natalia N NN Arndt Volker V Aronson Kristan J KJ Arun Banu B Auer Paul L PL Bacot François F Barrdahl Myrto M Baynes Caroline C Beckmann Matthias W MW Behrens Sabine S Benitez Javier J Bermisheva Marina M Bernstein Leslie L Blomqvist Carl C Bogdanova Natalia V NV Bojesen Stig E SE Bonanni Bernardo B Børresen-Dale Anne-Lise AL Brand Judith S JS Brauch Hiltrud H Brennan Paul P Brenner Hermann H Brinton Louise L Broberg Per P Brock Ian W IW Broeks Annegien A Brooks-Wilson Angela A Brucker Sara Y SY Brüning Thomas T Burwinkel Barbara B Butterbach Katja K Cai Qiuyin Q Cai Hui H Caldés Trinidad T Canzian Federico F Carracedo Angel A Carter Brian D BD Castelao Jose E JE Chan Tsun L TL David Cheng Ting-Yuan TY Seng Chia Kee K Choi Ji-Yeob JY Christiansen Hans H Clarke Christine L CL Collée Margriet M Conroy Don M DM Cordina-Duverger Emilie E Cornelissen Sten S Cox David G DG Cox Angela A Cross Simon S SS Cunningham Julie M JM Czene Kamila K Daly Mary B MB Devilee Peter P Doheny Kimberly F KF Dörk Thilo T Dos-Santos-Silva Isabel I Dumont Martine M Durcan Lorraine L Dwek Miriam M Eccles Diana M DM Ekici Arif B AB Eliassen A Heather AH Ellberg Carolina C Elvira Mingajeva M Engel Christoph C Eriksson Mikael M Fasching Peter A PA Figueroa Jonine J Flesch-Janys Dieter D Fletcher Olivia O Flyger Henrik H Fritschi Lin L Gaborieau Valerie V Gabrielson Marike M Gago-Dominguez Manuela M Gao Yu-Tang YT Gapstur Susan M SM García-Sáenz José A JA Gaudet Mia M MM Georgoulias Vassilios V Giles Graham G GG Glendon Gord G Goldberg Mark S MS Goldgar David E DE González-Neira Anna A Grenaker Alnæs Grethe I GI Grip Mervi M Gronwald Jacek J Grundy Anne A Guénel Pascal P Haeberle Lothar L Hahnen Eric E Haiman Christopher A CA Håkansson Niclas N Hamann Ute U Hamel Nathalie N Hankinson Susan S Harrington Patricia P Hart Steven N SN Hartikainen Jaana M JM Hartman Mikael M Hein Alexander A Heyworth Jane J Hicks Belynda B Hillemanns Peter P Ho Dona N DN Hollestelle Antoinette A Hooning Maartje J MJ Hoover Robert N RN Hopper John L JL Hou Ming-Feng MF Hsiung Chia-Ni CN Huang Guanmengqian G Humphreys Keith K Ishiguro Junko J Ito Hidemi H Iwasaki Motoki M Iwata Hiroji H Jakubowska Anna A Janni Wolfgang W John Esther M EM Johnson Nichola N Jones Kristine K Jones Michael M Jukkola-Vuorinen Arja A Kaaks Rudolf R Kabisch Maria M Kaczmarek Katarzyna K Kang Daehee D Kasuga Yoshio Y Kerin Michael J MJ Khan Sofia S Khusnutdinova Elza E Kiiski Johanna I JI Kim Sung-Won SW Knight Julia A JA Kosma Veli-Matti VM Kristensen Vessela N VN Krüger Ute U Kwong Ava A Lambrechts Diether D Le Marchand Loic L Lee Eunjung E Lee Min Hyuk MH Lee Jong Won JW Neng Lee Chuen C Lejbkowicz Flavio F Li Jingmei J Lilyquist Jenna J Lindblom Annika A Lissowska Jolanta J Lo Wing-Yee WY Loibl Sibylle S Long Jirong J Lophatananon Artitaya A Lubinski Jan J Luccarini Craig C Lux Michael P MP Ma Edmond S K ESK MacInnis Robert J RJ Maishman Tom T Makalic Enes E Malone Kathleen E KE Kostovska Ivana Maleva IM Mannermaa Arto A Manoukian Siranoush S Manson JoAnn E JE Margolin Sara S Mariapun Shivaani S Martinez Maria Elena ME Matsuo Keitaro K Mavroudis Dimitrios D McKay James J McLean Catriona C Meijers-Heijboer Hanne H Meindl Alfons A Menéndez Primitiva P Menon Usha U Meyer Jeffery J Miao Hui H Miller Nicola N Taib Nur Aishah Mohd NAM Muir Kenneth K Mulligan Anna Marie AM Mulot Claire C Neuhausen Susan L SL Nevanlinna Heli H Neven Patrick P Nielsen Sune F SF Noh Dong-Young DY Nordestgaard Børge G BG Norman Aaron A Olopade Olufunmilayo I OI Olson Janet E JE Olsson Håkan H Olswold Curtis C Orr Nick N Pankratz V Shane VS Park Sue K SK Park-Simon Tjoung-Won TW Lloyd Rachel R Perez Jose I A JIA Peterlongo Paolo P Peto Julian J Phillips Kelly-Anne KA Pinchev Mila M Plaseska-Karanfilska Dijana D Prentice Ross R Presneau Nadege N Prokofyeva Darya D Pugh Elizabeth E Pylkäs Katri K Rack Brigitte B Radice Paolo P Rahman Nazneen N Rennert Gadi G Rennert Hedy S HS Rhenius Valerie V Romero Atocha A Romm Jane J Ruddy Kathryn J KJ Rüdiger Thomas T Rudolph Anja A Ruebner Matthias M Rutgers Emiel J T EJT Saloustros Emmanouil E Sandler Dale P DP Sangrajrang Suleeporn S Sawyer Elinor J EJ Schmidt Daniel F DF Schmutzler Rita K RK Schneeweiss Andreas A Schoemaker Minouk J MJ Schumacher Fredrick F Schürmann Peter P Scott Rodney J RJ Scott Christopher C Seal Sheila S Seynaeve Caroline C Shah Mitul M Sharma Priyanka P Shen Chen-Yang CY Sheng Grace G Sherman Mark E ME Shrubsole Martha J MJ Shu Xiao-Ou XO Smeets Ann A Sohn Christof C Southey Melissa C MC Spinelli John J JJ Stegmaier Christa C Stewart-Brown Sarah S Stone Jennifer J Stram Daniel O DO Surowy Harald H Swerdlow Anthony A Tamimi Rulla R Taylor Jack A JA Tengström Maria M Teo Soo H SH Beth Terry Mary M Tessier Daniel C DC Thanasitthichai Somchai S Thöne Kathrin K Tollenaar Rob A E M RAEM Tomlinson Ian I Tong Ling L Torres Diana D Truong Thérèse T Tseng Chiu-Chen CC Tsugane Shoichiro S Ulmer Hans-Ulrich HU Ursin Giske G Untch Michael M Vachon Celine C van Asperen Christi J CJ Van Den Berg David D van den Ouweland Ans M W AMW van der Kolk Lizet L van der Luijt Rob B RB Vincent Daniel D Vollenweider Jason J Waisfisz Quinten Q Wang-Gohrke Shan S Weinberg Clarice R CR Wendt Camilla C Whittemore Alice S AS Wildiers Hans H Willett Walter W Winqvist Robert R Wolk Alicja A Wu Anna H AH Xia Lucy L Yamaji Taiki T Yang Xiaohong R XR Har Yip Cheng C Yoo Keun-Young KY Yu Jyh-Cherng JC Zheng Wei W Zheng Ying Y Zhu Bin B Ziogas Argyrios A Ziv Elad E Lakhani Sunil R SR Antoniou Antonis C AC Droit Arnaud A Andrulis Irene L IL Amos Christopher I CI Couch Fergus J FJ Pharoah Paul D P PDP Chang-Claude Jenny J Hall Per P Hunter David J DJ Milne Roger L RL García-Closas Montserrat M Schmidt Marjanka K MK Chanock Stephen J SJ Dunning Alison M AM Edwards Stacey L SL Bader Gary D GD Chenevix-Trench Georgia G Simard Jacques J Kraft Peter P Easton Douglas F DF
Nature 20171023 7678
Breast cancer risk is influenced by rare coding variants in susceptibility genes, such as BRCA1, and many common, mostly non-coding variants. However, much of the genetic contribution to breast cancer risk remains unknown. Here we report the results of a genome-wide association study of breast cancer in 122,977 cases and 105,974 controls of European ancestry and 14,068 cases and 13,104 controls of East Asian ancestry. We identified 65 new loci that are associated with overall breast cancer risk ...[more]