Ontology highlight
ABSTRACT:
SUBMITTER: Masuno H
PROVIDER: S-EPMC3708370 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Masuno Hiroyuki H Ikura Teikichi T Morizono Daisuke D Orita Isamu I Yamada Sachiko S Shimizu Masato M Ito Nobutoshi N
Journal of lipid research 20130530 8
The secondary bile acid lithocholic acid (LCA) and its derivatives act as selective modulators of the vitamin D receptor (VDR), although their structures fundamentally differ from that of the natural hormone 1α,25-dihydroxyvitamin D3 [1,25(OH)2D3)]. Here, we have determined the crystal structures of the ligand-binding domain of rat VDR (VDR-LBD) in ternary complexes with a synthetic partial peptide of the coactivator MED1 (mediator of RNA polymerase II transcription subunit 1) and four ligands, ...[more]