Ontology highlight
ABSTRACT:
SUBMITTER: Yoshihara A
PROVIDER: S-EPMC8773473 | biostudies-literature | 2022 Jan
REPOSITORIES: biostudies-literature
Yoshihara Ayana A Kawasaki Haru H Masuno Hiroyuki H Takada Koki K Numoto Nobutaka N Ito Nobutoshi N Hirata Naoya N Kanda Yasunari Y Ishizawa Michiyasu M Makishima Makoto M Kagechika Hiroyuki H Tanatani Aya A
Biomolecules 20220114 1
1α,25-Dihydroxyvitamin D<sub>3</sub> [1α,25(OH)<sub>2</sub>D<sub>3</sub>, <b>1</b>] is an active form of vitamin D<sub>3</sub> and regulates various biological phenomena, including calcium and phosphate homeostasis, bone metabolism, and immune response via binding to and activation of vitamin D receptor (VDR). Lithocholic acid (LCA, <b>2</b>) was identified as a second endogenous agonist of VDR, though its potency is very low. However, the lithocholic acid derivative <b>3</b> (<b>Dcha-20</b>) is ...[more]