Ontology highlight
ABSTRACT:
SUBMITTER: Ananth P
PROVIDER: S-EPMC3708525 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Ananth Prakash P Goldsmith Gunaseelan G Yathindra Narayanarao N
RNA (New York, N.Y.) 20130801 8
Non-Watson-Crick pairs like the G·U wobble are frequent in RNA duplexes. Their geometric dissimilarity (nonisostericity) with the Watson-Crick base pairs and among themselves imparts structural variations decisive for biological functions. Through a novel circular representation of base pairs, a simple and general metric scheme for quantification of base-pair nonisostericity, in terms of residual twist and radial difference that can also envisage its mechanistic effect, is proposed. The scheme i ...[more]