Ontology highlight
ABSTRACT:
SUBMITTER: Henderson CA
PROVIDER: S-EPMC3708529 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
RNA (New York, N.Y.) 20130626 8
OxyS and RprA are two small noncoding RNAs (sRNAs) that modulate the expression of rpoS, encoding an alternative sigma factor that activates transcription of multiple Escherichia coli stress-response genes. While RprA activates rpoS for translation, OxyS down-regulates the transcript. Crucially, the RNA binding protein Hfq is required for both sRNAs to function, although the specific role played by Hfq remains unclear. We have investigated RprA and OxyS interactions with Hfq using biochemical an ...[more]