Ontology highlight
ABSTRACT:
SUBMITTER: Andrabi SA
PROVIDER: S-EPMC3709257 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Andrabi Shaida A SA Kang Ho Chul HC Haince Jean-François JF Lee Yun-Il YI Zhang Jian J Chi Zhikai Z West Andrew B AB Koehler Raymond C RC Poirier Guy G GG Dawson Ted M TM Dawson Valina L VL
Nature medicine 20110522 6
Glutamate acting on N-methyl-D-aspartate (NMDA) receptors induces neuronal injury following stroke, through activation of poly(ADP-ribose) polymerase-1 (PARP-1) and generation of the death molecule poly(ADP-ribose) (PAR) polymer. Here we identify Iduna, a previously undescribed NMDA receptor-induced survival protein that is neuroprotective against glutamate NMDA receptor-mediated excitotoxicity both in vitro and in vivo and against stroke through interfering with PAR polymer-induced cell death ( ...[more]