Ontology highlight
ABSTRACT:
SUBMITTER: Ranaei-Siadat E
PROVIDER: S-EPMC3710363 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
RNA biology 20130401 4
In bacteria, trans-translation rescues stalled ribosomes by the combined action of tmRNA (transfer-mRNA) and its associated protein SmpB. The tmRNA 5' and 3' ends fold into a tRNA-like domain (TLD), which shares structural and functional similarities with tRNAs. As in tRNAs, the UUC sequence of the T-arm of the TLD is post-transcriptionally modified to m (5)UψC. In tRNAs of gram-negative bacteria, formation of m (5)U is catalyzed by the SAM-dependent methyltransferase TrmA, while formation of m ...[more]