Dataset Information

Clinical associations of the metabolic syndrome in systemic lupus erythematosus: data from an international inception cohort.

ABSTRACT:

Background

The metabolic syndrome (MetS) may contribute to increased cardiovascular risk in systemic lupus erythematosus (SLE). We aimed to examine the association of demographic factors, lupus phenotype and therapy exposure with the presence of MetS.

Methods

The Systemic Lupus International Collaborating Clinics Registry for Atherosclerosis inception cohort enrolled recently diagnosed (<15 months) SLE patients from 30 centres across 11 countries from 2000. Clinical, laboratory and therapeutic data were collected according to a standardised protocol. MetS was defined according to the 2009 consensus statement from the International Diabetes Federation. Univariate and backward stepwise multivariate logistic regression were used to assess the relationship of individual variables with MetS.

Results

We studied 1686 patients, of whom 1494 (86.6%) had sufficient data to determine their MetS status. The mean (SD) age at enrolment and disease duration was 35.2 years (13.4) and 24.1 weeks (18.0), respectively. MetS was present at the enrolment visit in 239 (16%). In backward stepwise multivariable regression analysis, higher daily average prednisolone dose (mg) (OR 1.02, 95% CI 1.00 to 1.03), older age (years) (OR 1.04, 95% CI 1.03 to 1.06), Korean (OR 6.33, 95% CI 3.68 to 10.86) and Hispanic (OR 6.2, 95% CI 3.78 to 10.12) ethnicity, current renal disease (OR 1.79, 95% CI 1.14 to 2.80) and immunosuppressant use (OR 1.81, 95% CI 1.18 to 2.78) were associated with MetS.

Conclusions

Renal lupus, higher corticosteroid doses, Korean and Hispanic ethnicity are associated with MetS in SLE patients. Balancing disease control and minimising corticosteroid exposure should therefore be at the forefront of personalised treatment decisions in SLE patients.

SUBMITTER: Parker B

PROVIDER: S-EPMC3711497 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature

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Publications

Clinical associations of the metabolic syndrome in systemic lupus erythematosus: data from an international inception cohort.

Parker Ben B Urowitz Murray B MB Gladman Dafna D DD Lunt Mark M Bae Sang-Cheol SC Sanchez-Guerrero Jorge J Romero-Diaz Juanita J Gordon Caroline C Wallace Daniel J DJ Clarke Ann E AE Bernatsky Sasha S Ginzler Ellen M EM Isenberg David A DA Rahman Anisur A Merrill Joan T JT Alarcón Graciela S GS Fessler Barri J BJ Fortin Paul R PR Hanly John G JG Petri Michelle M Steinsson Kristjan K Dooley Mary-Anne MA Manzi Susan S Khamashta Munther A MA Ramsey-Goldman Rosalind R Zoma Asad A AA Sturfelt Gunnar K GK Nived Ola O Aranow Cynthia C Mackay Meggan M Ramos-Casals Manuel M van Vollenhoven Raymond F RF Kalunian Kenneth C KC Ruiz-Irastorza Guillermo G Lim Sam S Kamen Diane L DL Peschken Christine A CA Inanc Murat M Bruce Ian N IN

Annals of the rheumatic diseases 20120903 8

<h4>Background</h4>The metabolic syndrome (MetS) may contribute to increased cardiovascular risk in systemic lupus erythematosus (SLE). We aimed to examine the association of demographic factors, lupus phenotype and therapy exposure with the presence of MetS.<h4>Methods</h4>The Systemic Lupus International Collaborating Clinics Registry for Atherosclerosis inception cohort enrolled recently diagnosed (<15 months) SLE patients from 30 centres across 11 countries from 2000. Clinical, laboratory an ...[more]

PMID: 22945501

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Dataset Information

Clinical associations of the metabolic syndrome in systemic lupus erythematosus: data from an international inception cohort.

Background

Methods

Results

Conclusions

Publications

Clinical associations of the metabolic syndrome in systemic lupus erythematosus: data from an international inception cohort.

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