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Impact of early disease factors on metabolic syndrome in systemic lupus erythematosus: data from an international inception cohort.


ABSTRACT: BACKGROUND:The metabolic syndrome (MetS) may contribute to the increased cardiovascular risk in systemic lupus erythematosus (SLE). We examined the association between MetS and disease activity, disease phenotype and corticosteroid exposure over time in patients with SLE. METHODS:Recently diagnosed (<15?months) patients with SLE from 30 centres across 11 countries were enrolled into the Systemic Lupus International Collaborating Clinics (SLICC) Inception Cohort from 2000 onwards. Baseline and annual assessments recorded clinical, laboratory and therapeutic data. A longitudinal analysis of factors associated with MetS in the first 2?years of follow-up was performed using random effects logistic regression. RESULTS:We studied 1150 patients with a mean (SD) age of 34.9 (13.6) years and disease duration at enrolment of?24.2 (18.0) weeks. In those with complete data, MetS prevalence was 38.2% at enrolment, 34.8% at year 1 and 35.4% at year 2. In a multivariable random effects model that included data from all visits, prior MetS status, baseline renal disease, SLICC Damage Index >1, higher disease activity, increasing age and Hispanic or Black African race/ethnicity were independently associated with MetS over the first 2?years of follow-up in the cohort. CONCLUSIONS:MetS is a persistent phenotype in a significant proportion of patients with SLE. Renal lupus, active inflammatory disease and damage are SLE-related factors that drive MetS development while antimalarial agents appear to be protective from early in the disease course.

SUBMITTER: Parker B 

PROVIDER: S-EPMC4515988 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature

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Impact of early disease factors on metabolic syndrome in systemic lupus erythematosus: data from an international inception cohort.

Parker Ben B   Urowitz Murray B MB   Gladman Dafna D DD   Lunt Mark M   Donn Rachelle R   Bae Sang-Cheol SC   Sanchez-Guerrero Jorge J   Romero-Diaz Juanita J   Gordon Caroline C   Wallace Daniel J DJ   Clarke Ann E AE   Bernatsky Sasha S   Ginzler Ellen M EM   Isenberg David A DA   Rahman Anisur A   Merrill Joan T JT   Alarcón Graciela S GS   Fessler Barri J BJ   Fortin Paul R PR   Hanly John G JG   Petri Michelle M   Steinsson Kristjan K   Dooley Mary Anne MA   Manzi Susan S   Khamashta Munther A MA   Ramsey-Goldman Rosalind R   Zoma Asad A AA   Sturfelt Gunnar K GK   Nived Ola O   Aranow Cynthia C   Mackay Meggan M   Ramos-Casals Manuel M   van Vollenhoven Ronald F RF   Kalunian Kenneth C KC   Ruiz-Irastorza Guillermo G   Lim S Sam SS   Kamen Diane L DL   Peschken Christine A CA   Inanc Murat M   Bruce Ian N IN  

Annals of the rheumatic diseases 20140401 8


<h4>Background</h4>The metabolic syndrome (MetS) may contribute to the increased cardiovascular risk in systemic lupus erythematosus (SLE). We examined the association between MetS and disease activity, disease phenotype and corticosteroid exposure over time in patients with SLE.<h4>Methods</h4>Recently diagnosed (<15 months) patients with SLE from 30 centres across 11 countries were enrolled into the Systemic Lupus International Collaborating Clinics (SLICC) Inception Cohort from 2000 onwards.  ...[more]

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